TARGETING SPHK1/2 BY SKI-178 INHIBITS PROSTATE CANCER CELL GROWTH

Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth

Abstract Sphingosine kinases (SphK), including SphK1 and SphK2, are important enzymes promoting progression of prostate cancer.SKI-178 is a novel and highly potent SphK1/2 dual inhibitor.We here tested the potential anti-prostate Grill Dish Insert cancer cell activity of SKI-178.Bioinformatics analyses and results from local tissues demonstrated th

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A Rate of Change and Center of Gravity Approach to Calculating Composite Indicator Thresholds: Moving from an Empirical to a Theoretical Perspective

A composite indicator (CI) is the mathematical aggregation of sub-dimension (local) indicators used to provide an overall score for the multidimensional concept being measured.CIs are widely used to assess the benefits or risks in human endeavors, such as by creating life satisfaction indices or disaster risk indicators.One important aspect of the

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